Pantheons

Pantheons are a mechanic added to Godhome. They feature a select set of bosses to combat before reaching the "Peak" of each Pantheon and facing the unique final boss of each challenge. Most bosses, with the exception of the final bosses, need to be defeated outside Godhome first before the Pantheon can be accessed that contains those bosses.

Completing the first three Pantheons will also unlock the Godseeker Mode.

The other exceptions to the general unlocking process there are as follows:

God Tamer will be unlocked regardless of whether she has been faced.
Grey Prince Zote will be skipped and will not count as an unlock requirement for the third pantheon if he was not defeated in the base game, including if Zote was left to die.
Lost Kin, Soul Tyrant, Failed Champion and White Defender will all be automatically unlocked once their real-world counterpart is defeated.
Nightmare King Grimm will appear if he has been faced or not and will not count as an unlock condition.
Vengefly King is always unlocked regardless of whether it was encountered.

Bindings
Bindings are optional challenges that can be applied to each separate Pantheon. Any combination of them can be applied. If all bindings are selected they will glow a radiant yellow. Completing Pantheons with bindings are requisites to access certain content such as extra Lifeblood Cocoons in each Pantheon's Hot Spring Room and the Land of Storms (see the respective pages for more information).
	NAIL BINDING Reduces nail damage to 80% or sets it to 13 if the damage is above 13. Nail Arts damage is calculated based on this damage. (Note: This binding does NOT affect the damage of some nail damage based charms, like Sharp Shadow, Thorns of Agony and Dreamshield.)
	SHELL BINDING Limits the Knight's maximum available masks to four, but does not affect Lifeblood masks or masks granted by Fragile Heart or Unbreakable Heart.
	CHARMS BINDING Unequips all charms and prevents equipping them again.
	SOUL BINDING Allows only 33% SOUL to be gathered and disables SOUL vessels, allowing for one Focus to heal or one Spell cast.

Pantheons
Pantheon of the Master Features bosses that can usually be encountered very early on. The final bosses are Brothers Oro & Mato. For more wave information see here.
Pantheon of the Artist This pantheon contains bosses that can be fought early to mid game. The final boss is Paintmaster Sheo. For more wave information see here.
Pantheon of the Sage The bosses here are generally found mid to late game. The final boss is Great Nailsage Sly. For more wave information see here. Note: Grey Prince Zote's lock icon will not appear if Zote was neglected and left to die.
Pantheon of the Knight This Pantheon is unlocked after the previous three Pantheons have been completed. It has most of the late game bosses, including several which deal two masks of damage. The final boss is Pure Vessel, a harder and faster version of the Hollow Knight. For more wave information see here.
Pantheon of Hallownest Access to this Pantheon is granted after the previous four Pantheons are completed and Void Heart has been acquired. This Pantheon contains all the bosses of the other four Pantheons, including their final bosses. Some of the bosses have a different arena or have a different variant, such as Sisters of Battle and Winged Nosk. Nightmare King Grimm can be encountered in this Pantheon as well. Its final boss is Absolute Radiance, a harder version of the Radiance. For more wave information see here.

Music
In addition to all the bosses making reappearances, all of them use new music when fought within the Pantheons:
Boss	Track
Vengefly King	Gods and Glory part A
Gruz Mother	Gods and Glory part A
False Knight	Furious Gods
Massive Moss Charger	Gods and Glory part A
Hornet Protector	Daughter of Hallownest
Gorb	Gods and Glory part B
Dung Defender	Gods and Glory part A
Soul Warrior	Gods and Glory part B
Tiso	Furious Gods
Brooding Mawlek	Haunted Foes (Percussion, High Vocals)
Brothers Oro & Mato	Furious Gods (Phase One) Gods and Glory part A (Phase Two)
Xero	Gods and Glory part A
Crystal Guardian	Gods and Glory part A
Soul Master	Gods and Glory part A (Phase One) Furious Gods (Phase Two)
Oblobbles	Gods and Glory part A
Mantis Lords	Sisters of Battle
Sisters of Battle	Mantis Lords (Phase One) Sisters of Battle (Phase Two)
Marmu	Gods and Glory part A
Flukemarm	Haunted Foes (Main, High Vocals)
Broken Vessel	Haunted Foes (Main)
Galien	Gods and Glory part A
Paintmaster Sheo	Gods and Glory part B
Hive Knight	Gods and Glory part A
Elder Hu	Gods and Glory part A
The Collector	Distorted Gods and Glory part B
God Tamer	Furious Gods + Colosseum Intensity 6
Grimm	Haunted Foes (Main, High Vocals) (Main, High Vocals, Strings) Flamespawner attack
Watcher Knight	Furious Gods
Uumuu	Gods and Glory part B
Nosk	Haunted Foes (Main, Percussion, High Vocals)
Winged Nosk	Haunted Foes (Full Ensemble)
Great Nailsage Sly	Gods and Glory part A (Phase One) Furious Gods (Phase Two)
Hornet Sentinel	Daughter of Hallownest
Enraged Guardian	Gods and Glory part A
Lost Kin	Haunted Foes (Percussion, High Vocals)
No Eyes	Haunted Foes (Main)
Traitor Lord	Furious Gods
White Defender	Gods and Glory part A
Soul Tyrant	Gods and Glory part A (Phase One) Furious Gods (Phase Two)
Markoth	Haunted Foes (Main, High Vocals)
Grey Prince Zote	Gods and Glory part B
Failed Champion	Furious Gods
Nightmare King Grimm	Haunted Foes (Full Ensemble)
Pure Vessel	Pure Vessel
Absolute Radiance	Radiance (Phase One-Five) Tuning (Phase Six)